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Gene expression profiling in uveal melanoma: technical reliability and correlation of molecular class with pathologic characteristics
Aug 2017
A 15-gene expression profile test has been clinically validated and is widely utilized in newly diagnosed uveal melanoma (UM) patients to assess metastatic potentila of the tumor. As most patients are treated with eye-sparing rediotherapy, there is limited tumor tissue available for testing, and technical reliability and success of prognostic testing are critical. This study assessed the analytical performance of the 15-gene expression test for UM and the correlation of molecular class with pathologic characteristics.
Publication: Diagnostic Pathology
Diagnostic distinction of malignant melanoma and benign nevi by a gene expression signature and correlation to clinical outcomes
Jul 2017
Large outcomes-proven validation cohort establishes high levels of sensitivity and specificity in melanomas with proven distant metastasis and nevi with 6+ years of event free follow-up.
Publication: Cancer Epidemiology, Biomarkers, and Prevention
Identification of high-risk cutaneous melanoma tumors is improved when combining the online American Joint Committee on Cancer individualized melanoma patient outcome prediction tool with a 31-gene expression profile–based classification
May 2017
Comparison and accuracy of the GEP in combination with risk determined using the web-based AJCC Individualized Melanoma Patient Outcome Prediction Tool.
Publication: Journal of the American Academy of Dermatology
Impact of a 31-gene expression profiling test for cutaneous melanoma on dermatologists clinical management decisions
May 2017
Risk appropriate management recommendations for implementing SLNB and imaging were more likely to be made following incorporation of DecisionDx-Melanoma test results.
Publication: Journal of Drugs and Dermatology
Pharmacogenetics-guided analgesics in major abdominal surgery: Further benefits within an enhanced recovery protocol
Mar 2017
Pharmacogenetics guidance resulted in frequent modifications of the analgesic program, resulting in excellent analgesia with a 50% reduction in narcotic consumption, and a reduced incidence of analgesic related side effects compared to our standard ERP.
Publication: The American Journal of Surgery
A tissue systems pathology test detects abnormalities associated with prevalent high-grade dysplasia and esophageal cancer in Barrett’s esophagus
Feb 2017
A tissue systems pathology test may provide an objective method to facilitate earlier therapeutic intervention of Barrett's esophagus patients.
Publication: Cancer Epidemiology, Biomarkers & Prevention
The influence of a gene expression signature on the treatment of diagnostically challenging melanocytic lesions
Jan 2017
MyPath Melanoma guides dermatologists in treatment decisions leading to a 72% reduction in re-excisions when the GEP result is benign.
Publication: Personalized Medicine
Contribution of pharmacogenetic testing to modeled medication change recommendations in a long-term care population with polypharmacy
Dec 2016
Among long-term care facility residents, polypharmacy is common, and often appropriate, given the need to treat multiple, complex, chronic conditions. Polypharmacy has, however, been associated with increased healthcare costs, adverse drug events, and drug interactions. The current study evaluates the potential medication cost savings of adding personalized pharmacogenetic information to traditional medication management strategies.
Publication: Drugs Aging
An independent validation of a gene expression signature to differentiate malignant melanoma from benign melanocytic nevi
Oct 2016
Establishes the performance of the gene expression signature in prospectively submitted cases with triple concordant diagnosis.
Publication: Cancer
The influence of a gene expression signature on the diagnosis and recommended treatment of melanocytic tumors by dermatopathologists
Oct 2016
Definitive diagnoses by dermatopathologists in challenging melanocytic lesions increased by 57% by incorporating the results of 23-GEP.
Publication: Medicine
A tissue systems pathology assay for high-risk Barrett’s esophagus
Oct 2016
Exploration of a tissue systems pathology approach to predict progression in patients with non-dysplastic Barrett's esophagus.
Publication: Cancer Epidemiology, Biomarkers & Prevention
Epigenetic reprogramming and aberrant expression of PRAME are associated with increased metastatic risk in class 1 and class 2 uveal melanomas
Jul 2016
We previously identified PRAME as a biomarker for metastatic risk in Class 1 uveal melanomas. In this study, we sought to define a threshold value for positive PRAME expression (PRAME+) in a large dataset, identify factors associated with PRAME expression, evaluate the prognostic value of PRAME in Class 2 uveal melanomas, and determine whether PRAME expression is associated with aberrant hypomethylation of the PRAME promoter.
Publication: Oncotarget