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Scientific evidence
Economic evaluation of implementing a novel pharmacogenomic test (IDgenetix®) to guide treatment of patients with depression and/or anxiety
Nov 2017
The treatment of actinic keratoses — the rule rather than the exception
Nov 2017
This work highlights a critical aspect of the physician-patient relationship—communication. As expected, the findings suggest that the verbiage used to describe actinic keratoses (AKs) can affect the patient’s decision to pursue treatment. Interestingly, regardless of how the question was framed, most patients preferred to treat these lesions.
Publication: JAMA Dermatol
Integrating skin cancer–related technologies into clinical practice
Oct 2017
11-member Melanoma Evolving Diagnostic Technologies Integration Group (MEDTIG) derived an algorithmic approach to systematically facilitate incorporating these technologies into the evaluation and management of suspicious PSLs.
Publication: Dermatologic Clinics
Interim analysis of survival in a prospective, multi-center registry cohort of cutaneous melanoma tested with a prognostic 31-gene expression profile test
Aug 2017
Prospective evaluation of the GEP performance in patients enrolled in two clinical registries for three primary endpoints recurrence-free (RFS), distant metastasis-free (DMFS), and overall survival (OS).
Publication: Journal of Hematology and Oncology
Signatures of field cancerization: a step towards earlier detection of esophageal adenocarcinoma
Aug 2017
Detection of the field effect in the clinical setting with validated, cost-effective diagnostic assays may increase the detection of HGD and EAC.
Publication: Translational Cancer Research
Gene expression profiling in uveal melanoma: technical reliability and correlation of molecular class with pathologic characteristics
Aug 2017
A 15-gene expression profile test has been clinically validated and is widely utilized in newly diagnosed uveal melanoma (UM) patients to assess metastatic potentila of the tumor. As most patients are treated with eye-sparing rediotherapy, there is limited tumor tissue available for testing, and technical reliability and success of prognostic testing are critical. This study assessed the analytical performance of the 15-gene expression test for UM and the correlation of molecular class with pathologic characteristics.
Publication: Diagnostic Pathology
Diagnostic distinction of malignant melanoma and benign nevi by a gene expression signature and correlation to clinical outcomes
Jul 2017
Large outcomes-proven validation cohort establishes high levels of sensitivity and specificity in melanomas with proven distant metastasis and nevi with 6+ years of event free follow-up.
Publication: Cancer Epidemiology, Biomarkers, and Prevention
Identification of high-risk cutaneous melanoma tumors is improved when combining the online American Joint Committee on Cancer individualized melanoma patient outcome prediction tool with a 31-gene expression profile–based classification
May 2017
Comparison and accuracy of the GEP in combination with risk determined using the web-based AJCC Individualized Melanoma Patient Outcome Prediction Tool.
Publication: Journal of the American Academy of Dermatology
Impact of a 31-gene expression profiling test for cutaneous melanoma on dermatologists clinical management decisions
May 2017
Risk appropriate management recommendations for implementing SLNB and imaging were more likely to be made following incorporation of DecisionDx-Melanoma test results.
Publication: Journal of Drugs and Dermatology
Pharmacogenetics-guided analgesics in major abdominal surgery: Further benefits within an enhanced recovery protocol
Mar 2017
Pharmacogenetics guidance resulted in frequent modifications of the analgesic program, resulting in excellent analgesia with a 50% reduction in narcotic consumption, and a reduced incidence of analgesic related side effects compared to our standard ERP.
Publication: The American Journal of Surgery
A tissue systems pathology test detects abnormalities associated with prevalent high-grade dysplasia and esophageal cancer in Barrett’s esophagus
Feb 2017
A tissue systems pathology test may provide an objective method to facilitate earlier therapeutic intervention of Barrett's esophagus patients.
Publication: Cancer Epidemiology, Biomarkers & Prevention
The influence of a gene expression signature on the treatment of diagnostically challenging melanocytic lesions
Jan 2017
MyPath Melanoma guides dermatologists in treatment decisions leading to a 72% reduction in re-excisions when the GEP result is benign.
Publication: Personalized Medicine